Esther's Publications
Contributions to Industry Research and Publications
With an unwavering commitment to advancing knowledge and providing benefits to the development of the Digital Health industries, Esther has garnered recognition as a distinguished author and researcher. Her extensive contributions of work exemplifies a profound understanding of the subject matter, encompassing groundbreaking studies, thought-provoking insights, and innovative approaches. Through meticulous research and eloquent prose, Esther has not only shaped the discourse in her respective domain but has also inspired countless readers and fellow leaders. This compilation of publications stands as a testament to Esther’s exceptional intellect, dedication, and contributions to help provide Precision Medicine to patients.
Artificial intelligence and Digital Pathology
Mark D. Zarella, David S. McClintock, Harsh Batra, Rama R. Gullapalli, Michael Valante, Vivian O. Tan, Shubham Dayal, Kei Shing Oh, Haydee Lara, Chris A. Garcia, Esther Abels, Artificial intelligence and digital pathology: clinical promise and deployment considerations, J. Med. Imag. 10(5), 051802 (2023), doi: 10.1117/1.JMI.10.5.051802.
https://digitalpathologyassociation.org/artificial-intelligence-and-digital-pathology-clinical-promise-and-deployment-considerations
Pharma
(efficacy, safety, and health economics registration studies)
Dahl V, Pendeville PE, Hollmann MW, Heier T, Abels EA, Blobner M. Safety and efficacy of sugammadex for the reversal of rocuronium- induced neuromuscular blockade in cardiac patients undergoing noncardiac surgery. Eur J Anaesthesiol. 2009 Oct;26(10):874-84
https://pubmed.ncbi.nlm.nih.gov/19455040/
X. Wu, H. Oerding, J. Liu, B. Vanacker, S. Yao, V. Dahl, L. Xiong, C. Claudius, Y. Yue, Y. Huang, E. Abels, H. Rietbergen and T. Woo. Rocuronium blockade reversal with sugammadex vs. neostigmine: randomized study in Chinese and Caucasian subjects. BMC Anesthesiology 2014, 14(53)
https://www.longdom.org/abstract/sugammadex-40-mg-kgsup1sup- reversal-of-deep-rocuroniuminducedneuromuscular-blockade-a- multicenter-study-in-chinese-and-c-49410.html
Rahe-Meyer N, Berger C, Wittmann M, Solomon C, Abels EA, Rietbergen H, Reuter DA. Recovery from prolonged deep rocuronium- induced neuromuscular blockade: A randomized comparison of sugammadex reversal with spontaneous recovery. Anaesthesist 2015 Jul; 64(7): 506-12.
https://pubmed.ncbi.nlm.nih.gov/26126940/
Reimbursement, Return on Investment, Total Product Life Cycle and Business Strategy in Digital Pathology
Laura Lasiter; Jennifer Samboy; Carla Leibowitz; Charles Mathews; Spencer Hoskyns; and Esther Abels. Aligning Reimbursement for Digital Pathology with its Value. The Journal of Precision Medicine; December 2020
https://www.thejournalofprecisionmedicine.com/the-journal-of- precision-medicine/aligning-reimbursement-for-digital-pathology- with-its-value/
Staci J. Kearney, Amanda Lowe, Jochen K. Lennerz, Anil Parwani, Marilyn M. Bui, Katy Wack, Gina Giannini and Esther Abels. Bridging the gap: the critical role of regulatory affairs and clinical affairs in the total product life cycle of pathology imaging devices software. Frontiers in medicine, November 2021
https://pubmed.ncbi.nlm.nih.gov/34869473/
Dirk Vossen, Jeppe Thagaard, Fabian Schneider Rasmus Norré Sørensen, Johan Doré, Esther Abels, Amanda Lowe, Mogens Vyberg and Michael Grunkin: Chapter 8 AI-Driven Precision Pathology: Challenges and Innovations in Tissue Biomarker Analysis for Diagnosis. Book: Artificial Intelligence Applications in Human Pathology, Ralf Huss and Michael Grunkin
https://www.worldscientific.com/doi/10.1142/9781800611399_0008
Research in Digital Pathology
Prarthana Shrestha, Rik Kneepkens, Gijs van Elswijk, Jeroen Vrijnsen, Roxana Ion, Dirk Verhagen, Esther Abels, Dirk Vossen, and Bas Hulsken. Objective and Subjective Assessment of Digital Pathology Image Quality. AIMS Medical Science. 2015 March; 2(1): 65-78
https://pubmed.ncbi.nlm.nih.gov/19455040/
Prarthana Shrestha, R Kneepkens, J Vrijnsen, D Vossen, E Abels and B Hulsken. A quantative approach to evaluate image quality of whole slide imaging scanners, J Pathol Inform 2016, 7:56
https://pubmed.ncbi.nlm.nih.gov/28197359/
Regulatory Science in Digital Pathology
Abels E., Pantanowitz L. Current state of the regulatory trajectory
for whole slide imaging devices in the USA. J Pathol Inform 2017;8:23
https://pubmed.ncbi.nlm.nih.gov/28584684/
Sanjay Mukhopadhyay, MD, Michael D. Feldman, MD, PhD, Esther Abels, MSc, et al. Whole Slide Imaging Versus Microscopy for Primary Diagnosis in Surgical Pathology, A multicenter blinded randomized non-inferiority study of 1992 cases (pivotal study), Am 12 of 13 J Surg Pathol 2017
https://pubmed.ncbi.nlm.nih.gov/28961557/
Abels E, Pantanowitz L, Aeffner F, Zarella MD, vd Laak, J, Bui MM, Vemuri VNP, Parwani AV, Gibbs J, Agosto-Arroyo E, Beck AH, Kozlowski, C. “Computational Pathology Definitions, Best Practices, and Recommendations for Regulatory Guidance: A White Paper from the Digital Pathology Association”. Journal of Pathology 2019 DOI:10.1002/path.5331
https://pubmed.ncbi.nlm.nih.gov/31355445/
Marble HD, Huang R, Dudgeon SN, Lowe A, Herrmann MD, Blakely S, Leavitt MO, Isaacs M, Hanna MG, Sharma A, Veetil J, Goldberg P, Schmid JH, Lasiter L, Gallas BD, Abels E, Lennerz JK. A regulatory science initiative to harmonize and standardize digital pathology and machine learning processes to speed up clinical innovation to patients. J Pathol Inform 2020;11:22
https://www.sciencedirect.com/science/article/pii/S215335392200 2516
Lara, Haydee MS, PhD; Li, Zaibo MD, PhD; Abels, Esther MS; Aeffner, Famke DVM, PhD; Bui, Marilyn M. MD, PhD; ElGabry, Ehab A. MD; Kozlowski, Cleopatra PhD; Montalto, Michael C. PhD; Parwani, Anil V. MD, PhD, MBA; Zarella, Mark D. PhD; Bowman, Douglas BSE; Rimm, David MD, PhD; Pantanowitz, Liron MD, MHA. Quantitative Image Analysis for Tissue Biomarker Use. Applied Immunohistochemistry & Molecular Morphology, 2021
https://pubmed.ncbi.nlm.nih.gov/33734106/
Artificial intelligence and Digital Pathology
Mark D. Zarella, David S. McClintock, Harsh Batra, Rama R. Gullapalli, Michael Valante, Vivian O. Tan, Shubham Dayal, Kei Shing Oh, Haydee Lara, Chris A. Garcia, Esther Abels, Artificial intelligence and digital pathology: clinical promise and deployment considerations, J. Med. Imag. 10(5), 051802 (2023), doi: 10.1117/1.JMI.10.5.051802.
https://digitalpathologyassociation.org/artificial-intelligence-and-digital-pathology-clinical-promise-and-deployment-considerations
Pharma
(efficacy, safety, and health economics registration studies)
Dahl V, Pendeville PE, Hollmann MW, Heier T, Abels EA, Blobner M. Safety and efficacy of sugammadex for the reversal of rocuronium- induced neuromuscular blockade in cardiac patients undergoing noncardiac surgery. Eur J Anaesthesiol. 2009 Oct;26(10):874-84
https://pubmed.ncbi.nlm.nih.gov/19455040/
X. Wu, H. Oerding, J. Liu, B. Vanacker, S. Yao, V. Dahl, L. Xiong, C. Claudius, Y. Yue, Y. Huang, E. Abels, H. Rietbergen and T. Woo. Rocuronium blockade reversal with sugammadex vs. neostigmine: randomized study in Chinese and Caucasian subjects. BMC Anesthesiology 2014, 14(53)
https://www.longdom.org/abstract/sugammadex-40-mg-kgsup1sup- reversal-of-deep-rocuroniuminducedneuromuscular-blockade-a- multicenter-study-in-chinese-and-c-49410.html
Rahe-Meyer N, Berger C, Wittmann M, Solomon C, Abels EA, Rietbergen H, Reuter DA. Recovery from prolonged deep rocuronium- induced neuromuscular blockade: A randomized comparison of sugammadex reversal with spontaneous recovery. Anaesthesist 2015 Jul; 64(7): 506-12.
https://pubmed.ncbi.nlm.nih.gov/26126940/
Reimbursement, Return on Investment, Total Product Life Cycle and Business Strategy in Digital Pathology
Laura Lasiter; Jennifer Samboy; Carla Leibowitz; Charles Mathews; Spencer Hoskyns; and Esther Abels. Aligning Reimbursement for Digital Pathology with its Value. The Journal of Precision Medicine; December 2020
https://www.thejournalofprecisionmedicine.com/the-journal-of- precision-medicine/aligning-reimbursement-for-digital-pathology- with-its-value/
Staci J. Kearney, Amanda Lowe, Jochen K. Lennerz, Anil Parwani, Marilyn M. Bui, Katy Wack, Gina Giannini and Esther Abels. Bridging the gap: the critical role of regulatory affairs and clinical affairs in the total product life cycle of pathology imaging devices software. Frontiers in medicine, November 2021
https://pubmed.ncbi.nlm.nih.gov/34869473/
Dirk Vossen, Jeppe Thagaard, Fabian Schneider Rasmus Norré Sørensen, Johan Doré, Esther Abels, Amanda Lowe, Mogens Vyberg and Michael Grunkin: Chapter 8 AI-Driven Precision Pathology: Challenges and Innovations in Tissue Biomarker Analysis for Diagnosis. Book: Artificial Intelligence Applications in Human Pathology, Ralf Huss and Michael Grunkin
https://www.worldscientific.com/doi/10.1142/9781800611399_0008
Research in Digital Pathology
Prarthana Shrestha, Rik Kneepkens, Gijs van Elswijk, Jeroen Vrijnsen, Roxana Ion, Dirk Verhagen, Esther Abels, Dirk Vossen, and Bas Hulsken. Objective and Subjective Assessment of Digital Pathology Image Quality. AIMS Medical Science. 2015 March; 2(1): 65-78
https://pubmed.ncbi.nlm.nih.gov/19455040/
Prarthana Shrestha, R Kneepkens, J Vrijnsen, D Vossen, E Abels and B Hulsken. A quantative approach to evaluate image quality of whole slide imaging scanners, J Pathol Inform 2016, 7:56
https://pubmed.ncbi.nlm.nih.gov/28197359/
Regulatory Science in Digital Pathology
Abels E., Pantanowitz L. Current state of the regulatory trajectory
for whole slide imaging devices in the USA. J Pathol Inform 2017;8:23
https://pubmed.ncbi.nlm.nih.gov/28584684/
Sanjay Mukhopadhyay, MD, Michael D. Feldman, MD, PhD, Esther Abels, MSc, et al. Whole Slide Imaging Versus Microscopy for Primary Diagnosis in Surgical Pathology, A multicenter blinded randomized non-inferiority study of 1992 cases (pivotal study), Am 12 of 13 J Surg Pathol 2017
https://pubmed.ncbi.nlm.nih.gov/28961557/
Abels E, Pantanowitz L, Aeffner F, Zarella MD, vd Laak, J, Bui MM, Vemuri VNP, Parwani AV, Gibbs J, Agosto-Arroyo E, Beck AH, Kozlowski, C. “Computational Pathology Definitions, Best Practices, and Recommendations for Regulatory Guidance: A White Paper from the Digital Pathology Association”. Journal of Pathology 2019 DOI:10.1002/path.5331
https://pubmed.ncbi.nlm.nih.gov/31355445/
Marble HD, Huang R, Dudgeon SN, Lowe A, Herrmann MD, Blakely S, Leavitt MO, Isaacs M, Hanna MG, Sharma A, Veetil J, Goldberg P, Schmid JH, Lasiter L, Gallas BD, Abels E, Lennerz JK. A regulatory science initiative to harmonize and standardize digital pathology and machine learning processes to speed up clinical innovation to patients. J Pathol Inform 2020;11:22
https://www.sciencedirect.com/science/article/pii/S215335392200 2516
Lara, Haydee MS, PhD; Li, Zaibo MD, PhD; Abels, Esther MS; Aeffner, Famke DVM, PhD; Bui, Marilyn M. MD, PhD; ElGabry, Ehab A. MD; Kozlowski, Cleopatra PhD; Montalto, Michael C. PhD; Parwani, Anil V. MD, PhD, MBA; Zarella, Mark D. PhD; Bowman, Douglas BSE; Rimm, David MD, PhD; Pantanowitz, Liron MD, MHA. Quantitative Image Analysis for Tissue Biomarker Use. Applied Immunohistochemistry & Molecular Morphology, 2021
https://pubmed.ncbi.nlm.nih.gov/33734106/
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